Liposome Allows The Best Drug Delivery Way

By Gabrielle Lambert


Liposome is basically a drug delivery bubble. It is made to resemblance the real cell, as a form of an artificial cell. It can be used in many different ways, injected, inhaled or in a form of a patch, cream or lotion. Liposomes can be unilamellar, small or large, usually known as SUV and LUV, or multilamillar vesicles, or MLV. They have characteristic shape and are very useful for transferring different drugs. That's why they are so interesting to modern medicine.

There are so many fields where they can be used, for example in food industry, agriculture or cosmetology. They are highly efficient carriers of all types of enzymes and supplements, and thanks to the fact they are actually very similar to the real cells, they have very high biocompatibility, comparing to any other carrier. It lowers the chances for different side effects, as well as improving the diffusion and absorption of the particular drug.

A liposome is actually very small bubble made of phospholipids, just like a cell membrane is built. They have a natural ability to target the exact area where needed, for example cancer. They can find and enter tumor sites, and release their content when in there. Tumor cells have different level of seals between cells, and liposomes can penetrate through their membranes.

They can carry pieces of DNA, delivering genes to cells as well. They protect DNA from degrading processes and can be targeted to specific tissues. Thanks to their bi-layered membranes, they are able to carry both positively and negatively charged molecules. Bubbles can be hydrophilic or lipophilic, or have both characteristics, according to specific needs.

Some drugs would be more effective if carried to targeted area this way. Traditional oral capsules and pills can have problems with gastric system, and acid might destroy them partially. There are also different issues with hydrolysis and solubility. Using this type of drug carriers will significantly improve the effectiveness of different drugs and prolong the circulation time.

If different drugs are taken orally, in form of pills or capsules, the majority of contents can become destroyed by gastric system, for example. If the contents is protected by natural bubble, all ingredients stay intact, and come to their destination. This became especially interesting in dietary and nutritional supplements industry lately, because this way the level of absorption is much higher.

Dietary and nutritional supplements can be carried within these small capsules to all targeting areas. Both lipophilic and hydrophilic nutritive supplements are effectively protected within those bubbles, and gastric system cannot harm them. Capsules ensure very high level of drug absorbtion, making those nutrients much more effective.

Nano liposome is especially small variation of the same technology. Their effects are even more impressive, although there are several factors that can affect the final quality of absorption. The quality of used raw material is crucial, as well as the method of manufacturing, size and actual stability of capsules used for each particular purpose. They are the key elements for their effectiveness.




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