There is a vesicle that is artificially prepared and used to administer nutrients and pharmaceutical drugs commonly known as a liposome which has a lipid bilayer. There are major types of this vesicle like the large and small unilamellar vesicles, cochleate and multilamellar vesicles. Micelles together with reverse micelles have monolayers therefore are not to be confused with liposomes. The first description of liposomes was done by Dr Alec D Bangham who was a British Haematologist in 1961 after discovering them while trying to test their new electron microscope.
The term used was derived from 2 Greek words namely lipo meaning fat and soma meaning body and this term was used due to the phospholipid composition of the liposomes. This vesicle has a hydrophobic membrane inside which an aqueous solution is encapsulated. Their primary use is delivery of targeted drugs but they can also be used as carriers of nutritional and dietary supplements.
After their versatile abilities were discovered, through clever implementation they are used orally to deliver certain nutritional and dietary supplements. There are few nutritional and dietary supplement manufacturers that are currently pioneering these benefits. The new liposomal science direction and employment has been adopted because capsules and tablets of traditional dietary and nutritional supplements happen to have a low bioavailability and absorption rate.
Natural lypophilic and hydrophilic nutrient are encapsulated within liposomes and this has made it such an effective method. Its effectiveness is seen when bypassing gastric system destructive elements and in aiding nutrient delivery to cells and tissues. During the manufacturing process the yielded percentage of liposomes is influenced by certain factors with far reaching effects. Long term stability of these artificial vesicles is borught about by these complex yet significant elements.
One of the factors is the preparation and actual manufacturing method of liposomes. Another factor is the type, quality and constitution of raw phospholipid used to formulate and manufacture the liposomes. There is also the ability to create particle sizes of homogeneous liposomes stable enough to hold the encapsulated payload. These key primary elements are the effective carrier foundation used to increase the bioavailability of oral dosages.
There is an approach used in biodetoxification of a drug which is similar to the delivery of drug through diffusion using liposomes other than using the direct cell fusion. This involves the injection of empty liposomes into the blood which have transmembrane pH gradient and then they scavenge the drug through which its toxic effects are stopped. Drug delivery through liposomes has another strategy which is targeting endocytosis events. There is a particular size range used when making liposomes which makes them viable and natural macrophage phagocytosis targets.
Liposomes can be used to transfect or transform DNA into host cells through a process that is known as lipofection. As carriers liposomes are used to deliver pesticides to plants, cosmetics to skins, dyes to textiles as well as enzymes and nutritional supplements to foods. The ultrasounds contrast can be enhanced using liposomes that act as microbubble contrast agents out shells.
By 2008 eleven drugs that use the liposomal delivery systems had been approved while six other drugs were still in clinical trials. Due to advanced liposome research, stealth liposomes have been created which can avoid detection by the immune system. There are certain anti cancerous drugs such as Daunorubicin, Doxil and Doxorubicin which are used when a tumor develops and provided through liposomes.
The term used was derived from 2 Greek words namely lipo meaning fat and soma meaning body and this term was used due to the phospholipid composition of the liposomes. This vesicle has a hydrophobic membrane inside which an aqueous solution is encapsulated. Their primary use is delivery of targeted drugs but they can also be used as carriers of nutritional and dietary supplements.
After their versatile abilities were discovered, through clever implementation they are used orally to deliver certain nutritional and dietary supplements. There are few nutritional and dietary supplement manufacturers that are currently pioneering these benefits. The new liposomal science direction and employment has been adopted because capsules and tablets of traditional dietary and nutritional supplements happen to have a low bioavailability and absorption rate.
Natural lypophilic and hydrophilic nutrient are encapsulated within liposomes and this has made it such an effective method. Its effectiveness is seen when bypassing gastric system destructive elements and in aiding nutrient delivery to cells and tissues. During the manufacturing process the yielded percentage of liposomes is influenced by certain factors with far reaching effects. Long term stability of these artificial vesicles is borught about by these complex yet significant elements.
One of the factors is the preparation and actual manufacturing method of liposomes. Another factor is the type, quality and constitution of raw phospholipid used to formulate and manufacture the liposomes. There is also the ability to create particle sizes of homogeneous liposomes stable enough to hold the encapsulated payload. These key primary elements are the effective carrier foundation used to increase the bioavailability of oral dosages.
There is an approach used in biodetoxification of a drug which is similar to the delivery of drug through diffusion using liposomes other than using the direct cell fusion. This involves the injection of empty liposomes into the blood which have transmembrane pH gradient and then they scavenge the drug through which its toxic effects are stopped. Drug delivery through liposomes has another strategy which is targeting endocytosis events. There is a particular size range used when making liposomes which makes them viable and natural macrophage phagocytosis targets.
Liposomes can be used to transfect or transform DNA into host cells through a process that is known as lipofection. As carriers liposomes are used to deliver pesticides to plants, cosmetics to skins, dyes to textiles as well as enzymes and nutritional supplements to foods. The ultrasounds contrast can be enhanced using liposomes that act as microbubble contrast agents out shells.
By 2008 eleven drugs that use the liposomal delivery systems had been approved while six other drugs were still in clinical trials. Due to advanced liposome research, stealth liposomes have been created which can avoid detection by the immune system. There are certain anti cancerous drugs such as Daunorubicin, Doxil and Doxorubicin which are used when a tumor develops and provided through liposomes.
About the Author:
If you are looking for more information about liposome, visit us online at www.encapsula.com . To learn more about how we can help you visit http://www.encapsula.com today.